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- The mechanism of telomerase activation is still not clear till now. 端粒酶的激活及其调控机制至今仍不清楚。
- No telomerase activity in human penile tissue. 人阴茎组织中无端粒酶活性。
- Telomerase is a new target of oncotherapy, the growth of tumor could be repressed by restraining telomerase activation. 端粒酶已成为新的肿瘤标志物及肿瘤治疗的新靶点,抑制肿瘤细胞端粒酶活性可望达到抑制肿瘤生长的目的。
- Telomerase is a new target of oncotherapy,the growth of tumor could be repressed by restraining telomerase activation. 端粒酶已成为新的肿瘤标志物及肿瘤治疗的新靶点,抑制肿瘤细胞端粒酶活性可望达到抑制肿瘤生长的目的。
- We summarize the dual role of telomeres in cancer, and the relationship between telomerase activation and tumours. 笔者综述了端粒的缩短所扮演的双重角色,以及端粒酶的激活与肿瘤之间的关系。
- Objective To observe the effects of hPOT1 overexpression on chromosome end-to-end fusions and telomerase activation in HeLa cells. 目的观察人端粒保护蛋白1(human protection of telom eres 1,hPOT1)基因过表达对HeLa细胞染色体端-端融合和端粒酶活性的影响。
- Compared with c ells treated with t-BHP alone, Rg1 pretreatment markedly decreased the shorteni ng of RTF length and resulted in telomerase activation. Rg1可明显减弱t BHP诱导细胞衰老的作用,减少t BHP引起的端粒长度缩短,同时可见细胞端粒酶活性的表达。
- Inverse correlation between telomerase activ ity and AI revealed in metastased cancer(P<0.05). 淋巴结转移组胃癌中的端粒酶活性与AI呈负相关(P<0.;05)。
- Conclusion Telomerase activation may appear in the intermediate and late stage of oral mucosal precancerous lesions, and may be one of the specfic markers in cell cancerization. 结论端粒酶激活出现在口腔粘膜癌前病变的中晚期阶段,是细胞癌变的特异性标志之一。
- Objective To investigate telomerase activity in patients with psoriasis. 目的探讨银屑病的端粒酶活性表达情况。
- BACKGROUND &AIM: To explore the significance and interaction of telomerase activation and expression of proliferating cell nucleus antigen (PCNA) in arsenic-induced skin lesion from coal burning. 摘要背景与目的:探讨端粒酶活性与增殖细胞核抗原(PCNA)在燃煤砷污染致皮肤病变中的作用及相互关系。
- Telomerase is very important for cell proliferation,cell insenecence,tumor diagnosis and tumor therapy.The investigation of Telomerase activation will have a very good perspective. 端粒酶在细胞的增殖、衰老及肿瘤诊断、治疗中起重要作用,对它的活性的研究会有很好的发展前景。
- The effect of bleomycini therapy on the telomerase activity of oral cancer patients. 平阳霉素化疗对口腔癌患者端粒酶活性的影响。
- Study on Alterations of Serum Telomerase Activity, SOD Activity and MDA Level of Chicken MD. 马立克氏病鸡血清中端粒酶、SOD活性与MDA含量变化的研究。
- Results: mTR-ASODN conjugated with LF 2000 could significantly inhibit telomerase activity of spermatogonia(P< 0.01). 结果 :端粒酶mTR的ASODN明显抑制精原细胞端粒酶活性 (P <0 .;0 1) ;
- METHODS: Flow cytometry was used to examine apoptosis and a PCR ELBA kit was used to detect telomerase activity. 方法:用流式细胞仪和PCR ELISA法分别检测NAC、NDMS、CAT或Quin 2与三氧化二砷共同作用于三种粒系白血病细胞后其凋亡和端粒酶活性的变 化。
- Abstract: Objective To investigate telomerase activity in patients with psoriasis. 文摘:目的探讨银屑病的端粒酶活性表达情况。
- Aim To establish a PCR MPH method for telomerase activity and its clinical applicatiom. 目的 建立聚合酶链反应 -微孔板杂交法检测端粒酶活性的方法及应用于临床。
- Detection of telomerase activity in bronchoscopic biopsied specimens may be helpful in the diagnosis of lung cancer. 检测支气管镜活检标本中端粒酶的活性可能有助于肺癌的诊断。
- Results:Telomerase activity was determined by PCR MPH accurately and specifically in various tumor tissu... 结论:两种方法均可用于临床检测,只是PCR-MPH方法更简单、方便一些。
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