Under acidic conditions, EOF velocity will be lower than the velocity of TFA anion.TFA anions thus turn out to move away from ESI/MS and the sensitivity loss caused by TFA can be reduced.

• 利用在液体结合式界面和低流速鞘流界面分别施加一电压，探讨所产生之电压差是否可使三氟醋酸停留在液体结合式界面之容槽中而不会进入质谱端，并且对液相层析峰之完整性作一评估。