To achieve high sensitivity, the minimum concentration of analyte detectable should be reproducibly measured by a signal distinguishable from the background, i.e., noise at zero dose of analyte (38).

• 为了达到高灵敏度，通过产生的信号与背景不同，即0剂量分析物的噪音，应该可重复的测到能检测到的最小分析物浓度。