Thrombosis,thromboembolism,and hemorrhage associated with anticoagulation in mechanical cardiac valve prosthesis are still the most common and severe complication after replacement for natural valve.

• 瓣膜血栓形成、血栓栓塞及抗凝有关的出血是机械瓣替换天然心脏瓣膜后最常见和最严重的并发症,也是术后的主要死亡原因。