Therefore, ATF gene transfer results in the suppression of spontaneous metastasis through competitive binding of exogenous ATF to urokinase receptor with urokinase.

• 上述结果揭示ATF基因转染后的肿瘤细胞通过ATF基因的表达与尿激酶竞争其受体的结合可在一定程度上抑制肿瘤细胞的恶性表型。