The low melting point derivatives and the hydrophilic derivatives of niclosamide were designed and prepared to enhance the transdemal rate of niclosamide.

• 研究了氯硝柳胺衍生物的透皮吸收.；和氯硝柳胺原药相比；氯硝柳胺的酯型前体药物对透皮速率并无显著影响；但前体药物的熔点越低；透皮速率越大;