The hyperinsulinemia and IR may be caused by a beta-cell hypersecretory response to the defective Peripheral sensitivity of insulin and by a decreased hepatic IS clearance with possibly increased urinary CP excretion.

• 其发生原因与组织对胰岛素的敏感性降低、胰岛素分泌异常增多以及胰岛素经肝脏降解减少有关,后者很可能伴有C肽经肾脏排泄增多。