The changes of brain water content and Evan blue(EB) were investigated on the model of infection brain edema induced by Pertussis Bacilli(PB) in 72 rats. Nimodipine was admenistred to show its effect on the PB induced brain edema.

• 观察百日咳菌液诱导的感染性脑水肿不同时间大鼠脑含水量和伊文思蓝（EB）含量的变化，以及Nimodipine对感染性脑水肿脑含水量和EB含量的影响。