Research indicated that PI3K and MAPK signal pathways were associated with biological behaviors such as cell migration, inflammation, cell proliferation and cell cycle regulation.

• 已有的研究表明PI3K和MAPK信号传导通路参与了细胞迁移、炎症反应、细胞增殖和细胞周期调控等一系列过程,在肾组织纤维化的发生发展中发挥重要作用。