Recent studies have found that p16 and p21, the specific suppressors of cyclin/CDK4/6, can regulate the phosphorylation of pRb and control the cell cycle progression through p16 - cyclm/CDK - Rb and p53 - p21 - cyclin/CDK - Rb pathway.

• 近年来的研究发现，许多基因通过信号传导途径调节pRb发生细胞周期依赖性磷酸化。 其中被广泛研究的是p16-cyclin/CDK-Rb途径和p53-p21-cyclin/CDK-Rb途径。