Objective: High mobility group box 1 protein (HMGB1) as a late-acting cytokine mediates lethality of sepsis and systemic inflammation.

• 目的:高迁移率族蛋白B1(HMGB1)作为一种晚期炎症介质,介导了脓毒症和其他系统性炎症的致死性效应。