Methods Propranolol was applied to make the psoriasis-like model of guinea pig.We topically applied APL on the ears of guinea pig and detected the expression of PCNA by immunohistochemistry method.

• 方法采用心得安法制备豚鼠耳廓银屑病样模型,APL外涂给药,免疫组化法检测皮损中细胞增殖核抗原(PCNA)变化并评价疗效。