In chromatin immunoprecipitation assay (ChIP), we found that CBP/p300 could acetylate histones on IL-5 promoter, resulting in increased accessibility of the open chromatin to the transcriptional machinery and therefore promoted gene transcription.

• 通过染色质免疫沉淀实验，我们还发现CBP/p300能够使IL-5启动子处的组蛋白高乙酰化。 这样产生一个相对开放的染色质构型，从而促进转录机器与DNA的结合，进而促进转录。