Familial amyotrophic lateral sclerosis can be related to mutations in the Cu/Zn superoxide dismutase gene (SOD1) located on chromosome 21q22.1.

• 家族性肌萎缩侧索硬化被认为与21号染色体长臂22.；1区带的铜/锌超氧化物岐化酶1（SOD1）基因突变有关。