Costimulatory molecules CD80 and CD86 play an important role in the activation of T cell mediated by protein carrier, then induced the production of anti-GM1 antibody, and then induced EAN. .

• 协同刺激分子CD80和CD86的表达通过载体蛋白活化T细胞,进而导致抗GM1-IgG抗体产生,在EAN的发病中起重要作用。