Con clu sion:The study suggests that the SE gene is the risk fac tor of RA in the population of Han na-tion ality in Shan dong area and the suscep ti bility to RA is related with HLA-DR4rather than HLA-DR1and HLA-DR10.

• 结论:山东地区RA易感性与共同表位(SE)有关,其中主要和HLA-DR4关联密切。 HLA-DR1,DR10不是RA易感基因。