Blimp-1 could help 2ME2 induce differentiation on myeloma cell lines by downregulating pax-5 mRNA and upregulating xbp-1 mRNA.

• Blimp-1可通过抑制pax-5 mRNA表达水平,从而提升xbp-1mRNA表达水平,促进骨髓瘤细胞分化。