Binding of the Ku heterodimer to DSBs triggers the recruitment of DNA-PK catalytic subunit and sealing of the DSBs by NHEJ.

• 异质二聚体对DNA双链断裂的束缚力引起DNA蛋白激酶催化亚基和DNA双链断裂连接通过非同源末端连接的方式得到补充。