Administration of anti IL 8 monoclonal antibodies in TBI prevented expression of IL 8, reduced the infiltration and accumulation of PMNL,attenuated local inflammation injury,reduced BBB permeability,and attenuated SBI after brain injury.

• 颅脑损伤后早期给予抗IL 8单抗治疗 ,可抑制IL 8的表达 ,抑制IL 8趋化PMNL的作用 ,减少组织中PMNL的浸润 ,减轻脑损伤后脑内炎症反应 ,降低血脑屏障通透性 ,减轻创伤性脑水肿 ,从而改善继发性脑损害。