A consistent estimator is gained by using a method based on the Akaike information criterion (AIC). Monte Carlo simulation are used to illustrate the method.

• 考虑不会导致风险显著增加的最高剂量,本文使用AIC(Akaike information criterion)方法得到满足相合性的估计,并且通过模拟的结果来说明AIC方法的优良性。