[Methods] The concentrations of chloroquine in the plasma of normal mice and the mice infected with the N or the RC strains of P. berghei were analyzed by reverse phase HPLC.

• [方法 ]应用反相高效液相色谱法分别测定正常小鼠、感染伯氏疟原虫N株和RC株小鼠血浆中的氯喹浓度 ,采用 3P87药物动力学分析软件对数据进行分析 ,从而获得有关药物动力学参数。