Acute dermal toxicity test was performed in healthy rat. 采用健康大白鼠进行皮肤急性毒性试验;
Acute oral toxicity on mouse and acute dermal toxicity experimentation on rabbits indicated that B25W-antibiotic was innoxious. 通过单因子和均匀设计实验，优化菌株B25W摇瓶发酵条件。 确定最佳发酵培养基：玉米粉0.
METHODS Acute dermal toxicity test and dermal irritation test were conducted in healthy rabbits,and dermal sensitivity test was performed in healthy guinea pigs. 方法对健康家兔进行皮肤急性毒性实验、皮肤刺激性实验,对健康豚鼠进行皮肤过敏实验。
Oral half lethal dose(LD 50) of thifensulfuron exceeds 5000mg/kg in rats, acute dermal toxicity(LD 50) exceeds 2000mg/kg, negative skin and mild eye irritation in rabbits, mild skin allergy in guinea pigs, with acute poisoning. 大鼠急性经口LD50 大于 5 0 0 0mg/kg ,经皮LD50 大于 2 0 0 0mg/kg。 家兔皮肤刺激试验阴性 ,轻度眼刺激性和弱致敏性。
Method: acute oral, acute dermal toxicity test and acute skin integrity and damage toxicity tests were carried out on mice, rats, and rabbits respectively, based on the "Guidelines for Research of New Drugs of Traditional Chinese Medicine". [方法 ]根据《中药新药研究指南 (药学、药理学、毒理学 )》提供的方法进行小鼠经口急性毒性试验、大鼠经皮急性毒性试验及家兔完整和破损皮肤急性毒性试验。
Both LD_(50) of acute oral toxicity and LD_(50) of acute dermal toxicity to mouse are (4 640 mg/kg) by Yintai technical material,and(3 160) mg/kg and(2 150) mg/kg by 20% Yintai EC coorespondingly. 仿生合成的银泰原药对大白鼠毒性试验,经口、经皮LD50均为4 640mg/kg,20%25银泰乳油对大白鼠毒性试验,经口LD50为3 160mg/kg,经皮LD50为2 150mg/kg;