Methods : We have chosen 37 CML cases, including 27 chronic phase (CP), 5 accelerated phase (AP) and 5 blast crisis (BC) cases . 方法:选取37例CML病人骨髓及口腔黏膜细胞的DNA标本,其中慢性期(chronic phase,CP)27例,加速期(accelerated phase,AP)5例,急变期(blast crisis,BC)5例。
The WT1 positive rate in 15 CML patients was 46.7%, the positive rate in 6 patients at blast crisis and 1 patient at accelerated phase were 100%, 0 in 8 patients at chronic phase. 15例CML的WT1基因表达阳性率为46.
METHODS: Polymerase chain reaction (PCR) was used to detect FLT3 gen e expression, and FLT3/ITD gene mutation in 53 CML patients of chronic phase, an d 34 CML patients of accelerated phase or blast crisis. 方法:采用聚合酶链反应(polymerasechainreaction,PCR)检测53例CML慢性期和34例CML加速期或急变期患者DNA水平FLT3基因及FLT3/ITD基因突变。
Background and objective:The natural disease history of chronic myeloid leukemia (CML) typicallyevolves 3 distinct clinical stages: chronic phase(CP), accelerated phase and blast crisis. 慢性粒细胞白血病(Chronic myeloid leukemia，CML)的自然病程可分为慢性期(Chronic phase，CP)，加速期(Accelerated phase，CP)和急变期(Blastcrisis phase，BP)。
Methods Five CML patients,2 in chronic phase(CP),1 in accelerated phase(AP) and 2 in blast crisis(BC), all comfirmed the presence of b3a2 bcr/abl mRNA by RT PCR(reverse transcriptase polymerase chain reaction). 方法 5例CML中慢性期 2例 ,加速期 1例 ,急变期 2例 ,均具b3a2型bcr/ablmRNA。
In malignant nephrosclerosis, the kidney demonstrates focal small hemorrhages. This is due to an accelerated phase of hypertension in which blood pressures are very high (such as 300/150 mm Hg). 恶性高血压导致小动脉纤维素样坏死。动脉损伤引起粉红色纤维素坏死物形成，因此称为纤维素样坏死。