The young leader was in full flower when he was struck down by a crippling disease. 这个年轻的领导人正值其事业到达顶峰之时，被一种致人残废的病症折磨倒了。
The young boy's successful struggle with a crippling disease won the hearts of the whole country when his story was told in the newspapers. 那个小男孩成功地与残疾作斗争的消息在报纸上刊登后，他赢得了全国人民的钦佩。
These "opportunities" sometimes appear to be hopeless problems, like a crippling disease, an uncontrollable habit or a situation in which one feels totally victimized without cause. 这些机遇有时候展现出来的是无望的困境，比如说一种绝症，一个无法摆脱的嗜好，或者一种困境让人觉得他是个毫无过错的的牺牲者。
a crippling disease which sentenced him to a lifetime in a wheelchair 把他终生束缚在轮椅上的残疾.
My father was a cripple, my mother in poor health. 我父亲是个残废人,我母亲身体又不好。