Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation.

• 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用，而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。