When she was 3 months old, many keratotic papules appeared on her neck, trunk and limbs, which were dirty gray or brown and horny papules, then the skin lesions spread over her whole body.

• 患者女,21岁。出生后3个月颈部、躯干、四肢即出现弥漫分布的黑褐色、疣状角化性丘疹。