Volatile anesthetic agents such as halothane,isoflurane,sevoflurane have demon- strated to attenuate [Ca~(2+)] i and inhibit activation of PKC,Rho kinase and p44/42 MAPK of VSM. Volatile anesthetics also depress release of EDRFs and open K_(ATP)channel.

• 吸入性麻醉药如氟烷、异氟醚、七氟醚等被证明通过抑制平滑肌[Ca~(2+)]i升高和PKC、Rho激酶、p44/42 MAPK的活性、同时也通过抑制EDRFs的释放和增加K_(ATP)通道的开放来扩张血管。