Verapamil increased the intracellular drug accumulation, and then obviously reversed the drug resistance to DNR, VCR, MIT, HHT, and VP 16 in K562/D cells, but not in the sensitive cells (K562/S).

• 异搏定使 K 5 6 2 / D细胞内药物积聚增加 ,明显地逆转了 K5 6 2 / D细胞对 DNR、VCR、MIT、HHT、VP- 16的耐药性 ,而对敏感细胞 K5 6 2 / S的耐药性无影响。