VEGF-induced metastatic colonies were surrounded by densely packed stromal cells before detectable angiogenesis, suggesting that VEGF is involved in the initiation of desmoplasia.

• 在血管形成之前，引入血管内皮生长因子表达的转移灶被高密度的间质细胞包裹，表明血管内皮生长因子参与结缔组织增生的过程。