Use a combination of an oral glucose-lowering drug (usually metformin) with NPH insulin twice daily (or once daily if initiated early), or twice-daily insulin mixes.

• 联合应用一种口服降糖药物（通常是二甲双胍）和NPH一日2次（开始早期应用一日一次），或者一日两次胰岛素混和制剂。