Urinary ceruloplasmin index and albumin index increased gradually with aging, with the lowest amplification in LETO rats, followed by OLETF rats with standard diet and high fat diet rich in n-3 PUFA.

• 方法：以LETO大鼠为同系对照，将OLETF大鼠分成A组、C组、D组和E组，分别予以标准饲料、高脂饲料、高脂富含n-6 PUFA和高脂富含n-3 PUFA饲料，分别在14周和24周对各组大鼠分别行OGTT，测定葡萄糖负荷后血糖、胰岛素和C肽，并计算胰岛素抵抗指数和胰岛素分泌指数。