Tuberculosis is an infectious disease worldwide with high morbidity and mortality,largely owing to persistence of tubercle bacillus and inadequacy of the current chemotherapy.

• 结核病仍为最具破坏性的细菌性疾病之一,发病率和死亡率都很高。结核分枝杆菌能侵入宿主免疫系统,在肺肉芽肿中持留,致使目前的抗结核药物无法杀灭菌体。