Trophoblast derived from first trimester pregnancy expressed MMP-2,MMP-9,TIMP-1 and uPA,but not TIMP-2,PA I-1.The first trimester and term DCM down-regulated the expression level of MMP-2,MMP-9,uPA and up-regulated theexpression level of TIMP-1,PAI-1.

• 早孕和晚孕DCM均能下调早孕滋养细胞MMP-2、MMP-9、uPAmRNA的表达，而上调TIMP-1mRNA的表达。 早孕、晚孕DCM均能诱导滋养细胞PAI-1mRNA的表达，但对TIMP-2mRNA的表达未见有影响。