Though the specific in citing agent remains unclear, the earliest histopathologic change in osteoarthritic joints is loss of mucopolysaccharide ground substance in the outermost layers of articular cartilage.

• 虽然特异性刺激因素尚不清楚，但是在骨关节炎关节中最早的组织病理学变化是在关节软骨的最外层中丧失粘液多糖基质。