This process seems to be modulated by CRF receptor 1. Evidences taken from CRF receptor 1 transgenic knockout mice, CRF receptor 1 antisense oligonucleotides work, as well as receptor 1 selective antagonist studies all suggested this conclusion.

• 研究表明；应激、焦虑与促肾上腺皮质激素释放因子(CRF)及其受体有关.