They got the raceme of bunolol at first and then bunolol was firstly resoluted with chiral column of HPLC by Lars Olsen in 1993. In 1995 the direct synthesis of levobunolol was reported by Alberto Stampa Diez Del Corral firstly.

• 1993年Lars Olsen等首次对其消旋体进行拆分； 1995年Alberto Stampa Diez Del Corral首次报道左布诺洛尔的直接合成法。