These results suggest that PDGF BB polypaptide may stimulate PDGF mRNA expression and promote the secretion in PASMC, and PDGF may have an important role in the proliferation of PASMC seen in the chronic hypoxic pulmonary hypertension.

• 本研究结果提示，PDGF?BB多肽能刺激肺动脉平滑肌细胞PDGFmRNA表达，促进其分泌，在慢性低氧性肺动脉高压血管平滑肌细胞增殖中具有重要作用