The toxic effect extends to the perivascular tissue, and the use of absolute ethanol has led to perivascular necrosis.Absolute ethanol can be delivered through the tiniest of catheters.

• 皮肤或黏膜膜坏死的发生率约10%25，可能是由于用药量大或药液渗入皮下、黏膜下组织所致。