The tissue inhibitor of metalloproteinases (TLMPs), which is major endogenous regulators of MMP activiesin, play an important role in the matrix synthesis and degradation balance.

• 基质金属蛋白酶特异性组织抑制剂（tissue inhibitor ofmetalloproteinases，TIMPs）是MMP活性的重要内源性调节因子，在基质合成与降解平衡中发挥重要作用。