The test showed that COFC could induce HPRT locus mutation in human bronchial epithelial and there was a linear relationship between the concentration of COFC and the mutation frequency(MF) of HPRT gene.

• 烹调油烟冷凝物诱发人支气管上皮细胞HPRT基因位点突变,且突变频率随着染毒浓度的增加而升高,突变频率与烹调油烟冷凝物浓度之间存在一定的剂量-效应关系,二甲基亚砜对HPRT基因位点突变有显著的拮抗作用。