The results of transcription activity assays show that overexpression of WDR26 in COS7 cells can remarkably inhibit the transcription-stimulation activity of ELK-1 and SRE, which are downstream effectors of MAPK pathway.

• 转录活性分析显示在COS7细胞中WDR26蛋白过表达可以使MAPK信号途径的两个下游转录因子ELK-1和SRE的转录激活活性显著下降。