The phosphorylation of G protein-coupled receptor (GPCR) by G protein-coupled receptor kinases (GRKs) under the stimulation with their specific agonists is the critical step to desensitization of GPCR.

• 激动剂诱导的G蛋白偶联受体激酶(GRK)对G蛋白偶联受体(GPCR)的磷酸化是受体脱敏的关键步骤。