The membrane fluidity and [Ca 2+ ]i of GEC were increased significantly in high concentration glucose induced injury of GEC by lipid peroxidation, and the higher the concentration of glucose, the more significant the effect as the cultured time went on.

• 高糖对肾小球内皮细胞可致过氧化损伤 ,使细胞膜流动性明显增高 ,细胞内钙含量增加 ,随着培养时间的延长 ,糖浓度愈高 ,作用愈明显。