The main role of MMP in angiogenesis, tumor growth and metastasis is degradation of extracellular matrix (ECM) and release and/or activation of growth factors through their degradative activity.

• 在血液系统恶性肿瘤中，白血病的浸润过程是多基因、多步骤、多阶段相互作用的级联反应,其中基质金属蛋白酶介导的细胞外基质及基底膜的降解过程,是肿瘤侵袭转移的一个关键步骤。