The lipid kinase phosphoinositied 3-OH kinase(PI3K) and its downstream target AKT,that is protein kinase B(PKB),plays important roles in carcinogenesis signal pathway reduced by kinds of PTK receptor.

• 脂类激酶PI3K和它的下游靶点Akt,即蛋白激酶B,在各种酪氨酸激酶受体诱导的致癌信号通路中发挥了重要的作用。