The latter two groups were subdivided into two time points groups: 4 and 8 weeks after modeling groups with 6 rats in each group.

• 取雄性SD大鼠30只,单纯随机分为3组,正常组6只,假手术组和模型组各12只,后2组又分为造模后4,8周2个时间点,每个时间点6只。