The genetic variations of drug related proteins including drug metabolism enzymes,drug transport proteins,and drug active receptors and/or targets are basic factors resulting in individual and ethnic differences in drug response.

• 除环境因素外,药物代谢酶、药物转运蛋白以及药物作用受体或靶位等药物反应相关蛋白的基因变异是引起药物反应个体差异和种族差异的根本原因。