The extremely high variability of HCV especially at the hypervariable region of its envelope protein draws back the research to develop a vaccine against it in the traditional ways.

• 由于HCV具有不同的基因型，基因突变率高，尤其是包膜蛋白中的高变区，使得传统的疫苗制备方法在HCV面前显得束手无策。