The epidemiology of KBD provides convincing evidence that selenium deficiency in the diet and high content humic acid (HA) in the drinking water are the main causative factors of the disease in China.

• 根据流行病学的调查，有证据显示出患区低硒食物与饮用水中的高量黄腐酸及腐植酸是造成大骨节病主要的致病因子。