The discovery of D3S1300 locus with highly frequent LOH suggested that FHIT gene located in this region might act as a candidate tumor suppressor gene in the development of colorectal carcinoma.

• 高频LOH位点D3S130 0的发现 ；提示 3p14.；2附近区域的FHIT基因可能作为肿瘤抑制基因在结直肠癌的发生发展中发挥作用。